PREDNIMON

Methylprednisolon for Injection 40mg/125mg

Description – Prednimon injection is available in dry powder injection

Indication –

• Acute Gouty Arthritis
• Acute and sub-acute bursitis
• Acute tenosynovitis
• Epicondylitis 
• Synovitis of osteoarthritis
• Spinal cord injury
• Acute respiratory distress syndrome

Dosage – 

• 10mg to 125mg IV/IM for every four hours as needed.
•  For Pediatric 0.03mg to 0.2mg per kg every 4 hours as needed.

Contraindications –

• Untreated Serious infections
• Documented Hypersensitivity
• Intrathecal administration
• Systemic fungal Infection

Adverse Drug Reactions –

• Iratogenic cushing syndrome
• Facial Rounding
• Puffiness
• Fat Deposition

Drug Interaction – can interact with aldesleukine, mifepristone, and other drugs that can also cause bleeding/bruising                       

Mechanism of Action – Methyl Prednisolone is a synthetic glucocorticoid that exhibits pleiotropic effects on a variety of physiological mechanism.

Their extensively effects is on inflammation and immunity 

The effect of glucocorticoid is depend on its association with intracellular glucocorticoid receptor and to a lesser extent mineral corticoid receptors.

Presentations – Prednimon is available in 40mg and 125mg injection