Sodium Valporate (Valporic acid) 100mg /ml inj

5 ml Vails

Indications:

Management of complex partial seizures and simple or complex absence seizures

Prophylaxis of migraine headaches

Therapy for bipolar disorder

Treatment of acute bipolar depression

Dosage:

100mg/ml

10-15mg/kg/day IV divided 12hr infused over 1hr, maximum dose 60mg/kg/day, do not exceed 14 days

Uses:

Epilepsy

Bipolar Disorder

Migraine headache

Contraindications:

Contraindicated in patients with known hypersensitivity to the drug, in patients with known urea cycle disorders, in active liver disease and family history of liver dysfunctions and in porphyria

Adverse Drug Reactions

Stomach pain

Diarrhea

Tremors in part of body or unusual eye movements

Feeling tired of sleepy

Headache

Weight gain

Drug Interaction:

Amitryptilline

Nortryptilline

Phenlzine

Imipenem

Mechanism of Action

Valproate is known to inhibit succinic semialdehyde dehydrogenase, this inhibition results in an increase succinic semialdehyde which acts as an inhibitor of GABA transaminase ultimately reducing GABA metabolism and increasing GABAergic neurotransmitter. As GABA is an inhibitory neurotransmitter, this increase results in increased inhibitory activity. A possible secondary contributor to cortical inhibition is a direct suppression of voltage gated sodium channel activity and indirect suppression through