Mesalamine Prolonged Release Tablets 1.2g

Indication:

Ulcerative Colitis

(Swelling and sores in the lining of colon)

Dosage:

For ulcerative colitis 400mg to be taken in two or three divided doses

To prevent further attacks, doctor will usally prescribe a dose of 4.8gm to be taken as four 1.2gm tablet once a day

Uses:

Mesalamine is used to treat and prevent flare-ups of mild to moderately active ulcerative colitis (an inflammatory bowel disease)

Contraindications:

Contraindications for 5-ASA include hypersensitivity to 5-ASA, Salicylates, or amino salicylates

Contraindications also include patients with severe renal or hepatic impairment

Adverse Drug Reactions:

Nausea

Gastrointestinal upset

Abdominal pain

Headaches

Nasopharyngitis

Rash

Arthralgias

Agranulocytosis

Aplastic Anemia

Myalgias

Bone marrow suppression

Drug Interaction:

Antacids: Antacid may disrupt the PH dependent formulations, this conditions can result in premature release and a decrease in the therapeutic effect of Mesalamine

Heparin: Mesalamine can enhance the pharmacologic effects of heparin and subsequently increase the risk of bleeding and bruising

Cardiac Glyocosides: Mesalamine may decrease the concentration of cardiac glycosides in the blood

Myelosuppressive agents (Mercaptopurine): Increase Bone marrow suppression risk

H2 Receptor blocker: H2 Receptor blocker may increase gastrointestinal pH, cause premature release of mesalamine and decrease the therapeutic effect

NSAIDs: Concomitant use of NSAIDs with mesalamine may decrease the metabolism of thiopurine analogs

Mechanism of Actions:

Mesalamine modulates the inflammatory response derived from the cyclooxygenase and lipooxygenase pathways,