Lizolis

Uses:

Pneumonia

Skin Infection

Certain infections that are resistant to another antibiotic

Contraindications:

Avoid using linezolid with adrenergic drugs such as pseudoephedrine, epinephrine, norepinephrine, dopamine or dobutamine due to the risk of hypertensive crisis.

Linezolid should not be used with patients taking serotonergic antidepressants or other medications like tricyclic antidepressants, bupropion, buspirone, tripants or meperidine which causes serotonin syndrome or neuroleptic malignant syndrome

Adverse Drug Reaction:

Chills

Confusion

Dizziness

Fainting

Fast Heartbeat

Fever

Lightheadedness

Pale skin

Rapid, shallow breathing

Rash

Trouble Breathing

Unusual bleeding

Unusual tiredness or weakness

Drug Interaction

Abaloparatide – Linezolid may increase the orthostatic hypotensive activities of Abaloparatide

Acarbose – Linezolid may increase the hypoglycemic activities of Acarbose

Acetylsalicylic acid – The risk of severity of bleeding and hemorrhage can be increased when linezolid is combined with Acetylsalicylic Acid

Mechanism of Action

Linezolid exerts its antibacterial effects by interfering with bacterial protein translation. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is essential for bacterial reproduction, thereby preventing bacteria from dividing

Point mutations in the bacterial 23S rRNA can lead to linezolid resistance, and the development linezolid resistant ENTEROCOCCUS FAECIUM and STAPHYLOCOCCUS AUREUS have been documented during its clinical use. As antimicrobial susceptibility patterns are geographically distinct.