Cefoperazone & Sulbactam For injection

Description: Celactum Inj. Is available in dry powder injection.

Indication & Dosage

Intravenous

Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra- abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynecological infections

Adult:  Ratio of sulbactam:cefoperazone is 1:1. Doses are expressed in terms of cefoperazone. Mild to moderate infections: 1-2 g daily, given in equally divided doses every 12 hr. Severe infections : Up to 4 g daily, given in equally divided doses every 12 hr ; max dose of sulbactam: 4 g daily.

Child:  Ratio of Sulbactam: cefoperazone is 1:1. Doses are expressed in terms of cefoperazone. Recommended doses: 20-40 mg/kg/day. Given in equally divided doses every 6-12hr. For serious infections: Up to 160 mg/kg/day, given in 2-4 equally divided doses may be used. Max dose of sulbactam: 80 mg/kg/day Renal impairment: Dose adjustments may be needed.

CefoperazoneSulbactam injection Uses

CefopreazoneSulbactam injection is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

- Intra-abdominal infections
- Urinary tract infection
- Infections of the urinary tract
- Bacterial infection of the respiratory tract
- Respiratory tract infections
- Surgical infections
- Bacterial Infection
- Peritonitis
- Intra-abdominal infections
- Endometritis
- Pelvic inflammatory disease
- Intra-abdominal infections
- Gynecological CefoperazoneSulbactam injection may also be used for purposes not listed here.

Contraindications:Hypersensitivity known allergy to penicillins

Special Precautions: Pregnancy lactation.

Adverse Drug Reactions:  Rash, skin reactions, fever, eosinophilia, urticarial and pruritus. Hematological Slight decreases in Hbconc and hematocrit value. GI effects, diarrhea or loose stools, nausea, and vomiting, mild, transient elevations in BUN and serum creatinine concentrations.

Drug Interactions:  With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity. With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and /or prolonged bleeding time.

Mechanism of Action:Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a β-lactamase inhibitor and acts primarily by irreversible inactivation of β-lactamases.

Presentation: Celactum is available in pack of 1.5 gm, 2 gm & 3 gm.